Domestic Box Office Results for 2021 Week 1 (3-Day Jan 1 - Jan 3)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -6.3% | 2,643 | -21 | $160,992 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 16.5% | 3,746 | 55 | $107,939 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 18.6% | 3,811 | 62 | $89,510 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -4.4% | 2,622 | -15 | $124,470 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 10.3% | 3,315 | 34 | $61,069 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 6.2% | 3,068 | 21 | $54,092 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -0.4% | 2,698 | -1 | $46,862 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -8.4% | 2,260 | -28 | $53,954 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 29.2% | 4,100 | 97 | $26,542 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -12.3% | 1,985 | -41 | $52,049 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -0.3% | 2,545 | -1 | $37,737 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -24.2% | 1,311 | -81 | $64,074 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 14.4% | 3,200 | 48 | $25,120 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 13.0% | 3,091 | 43 | $24,402 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 29.4% | 3,870 | 98 | $18,998 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 0.1% | 2,365 | - | $30,050 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -21.2% | 1,261 | -71 | $51,624 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 26.0% | 3,578 | 87 | $18,092 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -4.1% | 2,036 | -14 | $24,144 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 17.6% | 3,080 | 59 | $15,766 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 9.5% | 2,633 | 32 | $18,254 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -11.4% | 1,551 | -38 | $25,265 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -22.9% | 935 | -76 | $39,132 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 12.5% | 2,664 | 42 | $13,123 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -1.8% | 1,910 | -6 | $15,035 | $28,717,189 | 1 |