Domestic Box Office Results for 2021 Week 10 (3-Day Mar 5 - Mar 7)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 8.7% | 3,393 | 29 | $125,405 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 22.1% | 4,027 | 74 | $100,407 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -0.5% | 2,857 | -2 | $119,399 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 27.9% | 4,236 | 93 | $77,044 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -26.3% | 1,487 | -88 | $136,142 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 2.8% | 2,899 | 9 | $57,245 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 6.2% | 3,028 | 21 | $41,754 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 7.1% | 3,037 | 24 | $40,150 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -9.7% | 2,155 | -32 | $50,498 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -8.8% | 2,159 | -29 | $47,854 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 13.8% | 3,252 | 46 | $29,533 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 1.2% | 2,582 | 4 | $32,533 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 22.5% | 3,606 | 75 | $22,291 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 16.2% | 3,248 | 54 | $23,222 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 26.6% | 3,730 | 89 | $19,712 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -19.8% | 1,371 | -66 | $51,837 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 4.3% | 2,536 | 14 | $25,670 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -17.1% | 1,427 | -57 | $45,364 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 2.1% | 2,343 | 7 | $20,980 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 10.5% | 2,724 | 35 | $17,827 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -20.7% | 1,126 | -69 | $42,684 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 13.8% | 2,810 | 46 | $13,945 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 6.3% | 2,394 | 21 | $15,283 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -28.1% | 633 | -94 | $55,229 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -8.0% | 1,599 | -27 | $17,959 | $28,717,189 | 1 |