Domestic Box Office Results for 2021 Week 12 (3-Day Mar 19 - Mar 21)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 1.1% | 3,015 | 4 | $141,128 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 4.9% | 3,166 | 16 | $127,713 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 14.5% | 3,604 | 48 | $94,651 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 3.8% | 3,030 | 13 | $107,709 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 4.7% | 3,035 | 16 | $66,703 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 28.5% | 4,183 | 95 | $39,673 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 29.0% | 4,171 | 97 | $30,312 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 15.4% | 3,451 | 51 | $35,334 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -19.6% | 1,662 | -65 | $65,478 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 23.0% | 3,749 | 77 | $27,559 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -21.8% | 1,470 | -73 | $65,333 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -12.3% | 1,903 | -41 | $44,141 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -12.4% | 1,860 | -41 | $43,217 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 28.1% | 3,844 | 94 | $19,622 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 17.6% | 3,281 | 59 | $22,409 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 6.6% | 2,688 | 22 | $26,439 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 5.4% | 2,590 | 18 | $25,134 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 2.5% | 2,404 | 8 | $26,928 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 16.4% | 3,058 | 55 | $16,075 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -15.9% | 1,407 | -53 | $34,513 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 23.3% | 3,324 | 78 | $14,459 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -20.1% | 1,113 | -67 | $35,207 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -14.3% | 1,364 | -48 | $26,824 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -28.3% | 625 | -94 | $55,936 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 29.2% | 3,458 | 97 | $8,305 | $28,717,189 | 1 |