Domestic Box Office Results for 2021 Week 13 (3-Day Mar 26 - Mar 28)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -4.4% | 2,741 | -15 | $155,236 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -23.2% | 1,760 | -77 | $229,739 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 21.7% | 3,967 | 72 | $85,990 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 24.9% | 4,087 | 83 | $79,853 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 21.0% | 3,852 | 70 | $52,555 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 15.7% | 3,546 | 52 | $46,800 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -26.8% | 1,381 | -89 | $91,551 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 17.2% | 3,539 | 57 | $34,455 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -23.5% | 1,463 | -78 | $74,384 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 8.7% | 3,035 | 29 | $34,042 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 13.8% | 3,252 | 46 | $29,533 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 8.3% | 2,937 | 28 | $28,601 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 17.7% | 3,365 | 59 | $23,888 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -9.3% | 1,977 | -31 | $38,152 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -10.2% | 1,888 | -34 | $38,943 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -26.3% | 1,045 | -88 | $68,008 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -11.6% | 1,739 | -39 | $37,434 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -27.7% | 894 | -92 | $72,410 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -23.9% | 1,043 | -80 | $47,130 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 10.9% | 2,747 | 36 | $17,677 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -14.2% | 1,448 | -47 | $33,192 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -13.6% | 1,440 | -45 | $27,212 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -21.5% | 1,004 | -72 | $36,443 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -17.6% | 1,162 | -59 | $30,086 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -26.7% | 665 | -89 | $43,184 | $28,717,189 | 1 |