Domestic Box Office Results for 2021 Week 14 (3-Day Apr 2 - Apr 4)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -24.0% | 1,759 | -80 | $241,899 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 22.6% | 4,048 | 75 | $99,886 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 12.4% | 3,502 | 41 | $97,408 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -9.9% | 2,344 | -33 | $139,232 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 8.9% | 3,247 | 30 | $62,348 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 22.8% | 3,900 | 76 | $42,552 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -3.5% | 2,544 | -12 | $49,698 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 21.8% | 3,771 | 73 | $32,335 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -10.5% | 2,114 | -35 | $51,478 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -19.3% | 1,637 | -64 | $63,114 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 16.4% | 3,381 | 55 | $28,406 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -27.9% | 1,126 | -93 | $74,601 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -24.4% | 1,258 | -81 | $63,897 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 15.7% | 3,227 | 52 | $23,373 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -0.8% | 2,362 | -3 | $31,128 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -20.7% | 1,327 | -69 | $53,556 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -19.3% | 1,355 | -64 | $48,043 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 17.1% | 3,135 | 57 | $20,649 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -2.1% | 2,137 | -7 | $23,003 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 6.4% | 2,521 | 21 | $19,262 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 3.8% | 2,351 | 13 | $20,443 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -11.4% | 1,552 | -38 | $25,248 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -20.0% | 1,079 | -67 | $33,909 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 6.6% | 2,372 | 22 | $14,739 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 12.5% | 2,626 | 42 | $10,936 | $28,717,189 | 1 |