Domestic Box Office Results for 2021 Week 15 (3-Day Apr 9 - Apr 11)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 7.3% | 3,323 | 24 | $128,047 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -22.9% | 1,775 | -76 | $227,797 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -17.9% | 1,987 | -60 | $171,677 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -29.9% | 1,347 | -100 | $242,286 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 0.4% | 2,818 | 1 | $71,840 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 4.8% | 3,000 | 16 | $55,318 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -4.3% | 2,504 | -14 | $50,492 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 17.4% | 3,551 | 58 | $34,338 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 2.0% | 2,739 | 7 | $39,731 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -6.1% | 2,293 | -20 | $45,058 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -10.9% | 2,013 | -36 | $47,710 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -8.8% | 2,079 | -29 | $40,405 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -25.5% | 1,206 | -85 | $66,652 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 28.0% | 3,839 | 93 | $19,647 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 23.9% | 3,593 | 80 | $20,463 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 5.3% | 2,624 | 18 | $27,084 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 13.3% | 2,987 | 44 | $21,794 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 23.7% | 3,463 | 79 | $18,693 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -27.8% | 852 | -93 | $57,696 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 12.3% | 2,813 | 41 | $17,263 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -28.4% | 739 | -95 | $65,037 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 6.1% | 2,426 | 20 | $16,152 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -8.2% | 1,668 | -27 | $21,935 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 6.2% | 2,348 | 21 | $14,889 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -3.4% | 1,830 | -11 | $15,692 | $28,717,189 | 1 |