Domestic Box Office Results for 2021 Week 16 (3-Day Apr 16 - Apr 18)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -23.2% | 1,800 | -77 | $236,389 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -0.9% | 2,876 | -3 | $140,591 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -15.2% | 2,122 | -51 | $160,755 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 1.0% | 2,890 | 3 | $112,927 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -1.1% | 2,746 | -4 | $73,723 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -28.4% | 1,340 | -95 | $123,846 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -23.1% | 1,565 | -77 | $80,788 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 14.9% | 3,426 | 50 | $35,591 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 3.4% | 2,810 | 11 | $38,727 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 14.0% | 3,298 | 47 | $31,327 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 9.8% | 3,050 | 33 | $31,489 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 6.8% | 2,859 | 23 | $29,381 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 15.8% | 3,272 | 53 | $24,567 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -0.2% | 2,429 | -1 | $31,052 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 6.3% | 2,717 | 21 | $27,061 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -5.8% | 2,070 | -19 | $34,332 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 17.5% | 3,194 | 58 | $20,381 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -10.7% | 1,747 | -36 | $37,055 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -15.0% | 1,488 | -50 | $33,036 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -3.0% | 2,048 | -10 | $23,711 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 26.3% | 3,476 | 88 | $13,827 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -26.7% | 787 | -89 | $49,791 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -9.5% | 1,603 | -32 | $22,825 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 8.6% | 2,469 | 29 | $14,160 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 26.8% | 3,338 | 89 | $8,603 | $28,717,189 | 1 |