Domestic Box Office Results for 2021 Week 17 (3-Day Apr 23 - Apr 25)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -3.3% | 2,796 | -11 | $152,182 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -1.4% | 2,848 | -5 | $141,973 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 23.8% | 4,068 | 79 | $83,855 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -26.8% | 1,499 | -89 | $217,718 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -15.4% | 2,030 | -51 | $99,726 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -15.3% | 1,993 | -51 | $83,268 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -8.6% | 2,291 | -29 | $55,187 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 5.1% | 2,936 | 17 | $41,531 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 9.1% | 3,093 | 30 | $35,184 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 24.8% | 3,840 | 83 | $26,905 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 25.8% | 3,852 | 86 | $24,933 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 8.4% | 2,938 | 28 | $28,591 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 26.9% | 3,826 | 90 | $21,010 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -8.1% | 2,033 | -27 | $37,101 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 8.3% | 2,813 | 28 | $26,137 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -1.4% | 2,291 | -5 | $31,021 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 5.1% | 2,574 | 17 | $25,291 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 14.1% | 2,987 | 47 | $21,672 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 14.7% | 2,975 | 49 | $16,523 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 1.5% | 2,275 | 5 | $21,345 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -29.8% | 672 | -99 | $71,521 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 27.7% | 3,504 | 92 | $11,183 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 19.7% | 3,067 | 66 | $11,930 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 9.4% | 2,510 | 31 | $13,928 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 7.1% | 2,356 | 24 | $12,189 | $28,717,189 | 1 |