Domestic Box Office Results for 2021 Week 18 (3-Day Apr 30 - May 2)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -22.3% | 1,844 | -74 | $230,749 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 29.6% | 4,400 | 99 | $91,895 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -27.1% | 1,523 | -90 | $223,980 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -20.5% | 1,815 | -68 | $179,812 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 27.4% | 4,170 | 91 | $48,548 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 10.5% | 3,285 | 35 | $50,518 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 24.2% | 3,929 | 81 | $32,179 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 24.9% | 3,927 | 83 | $31,051 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -9.1% | 2,185 | -30 | $49,805 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -9.6% | 2,119 | -32 | $48,757 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 21.6% | 3,641 | 72 | $26,377 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -11.7% | 1,937 | -39 | $43,367 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -23.5% | 1,303 | -78 | $61,691 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -6.2% | 2,129 | -21 | $35,428 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -20.2% | 1,391 | -67 | $52,857 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 15.1% | 3,115 | 50 | $22,815 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 10.0% | 2,821 | 33 | $23,076 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 9.3% | 2,747 | 31 | $23,566 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -16.0% | 1,440 | -53 | $34,137 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 24.7% | 3,434 | 82 | $14,141 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -10.0% | 1,659 | -33 | $28,970 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -8.7% | 1,686 | -29 | $23,242 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 24.6% | 3,311 | 82 | $11,051 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -18.2% | 1,128 | -61 | $30,993 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -28.3% | 583 | -94 | $49,258 | $28,717,189 | 1 |