Domestic Box Office Results for 2021 Week 19 (3-Day May 7 - May 9)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 7.3% | 3,326 | 24 | $127,932 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -14.4% | 2,201 | -48 | $183,707 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 6.0% | 3,182 | 20 | $107,204 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 10.8% | 3,380 | 36 | $96,556 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 18.6% | 3,732 | 62 | $54,245 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -20.4% | 1,739 | -68 | $95,430 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -25.1% | 1,466 | -84 | $86,243 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -16.5% | 1,855 | -55 | $65,734 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -26.7% | 1,304 | -89 | $83,454 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 20.4% | 3,622 | 68 | $28,525 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -9.8% | 2,068 | -33 | $46,441 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 24.6% | 3,751 | 82 | $22,394 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 19.3% | 3,443 | 64 | $23,347 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 16.8% | 3,278 | 56 | $23,010 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 1.5% | 2,474 | 5 | $29,719 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -24.2% | 1,149 | -81 | $61,852 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -21.8% | 1,228 | -73 | $53,012 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 0.1% | 2,285 | - | $28,330 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 22.7% | 3,373 | 76 | $14,574 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 17.2% | 3,060 | 57 | $15,869 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -28.3% | 744 | -94 | $64,599 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 3.9% | 2,317 | 13 | $16,912 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -6.0% | 1,779 | -20 | $20,567 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 1.5% | 2,115 | 5 | $16,530 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 28.4% | 3,421 | 95 | $8,394 | $28,717,189 | 1 |