Domestic Box Office Results for 2021 Week 2 (3-Day Jan 8 - Jan 10)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 16.7% | 3,797 | 56 | $112,062 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -25.1% | 1,666 | -84 | $242,701 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -9.1% | 2,424 | -30 | $140,727 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -19.1% | 1,886 | -64 | $173,043 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 0.4% | 2,822 | 1 | $71,738 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -0.7% | 2,723 | -2 | $60,945 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -1.5% | 2,646 | -5 | $47,782 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -14.4% | 1,958 | -48 | $62,276 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -20.2% | 1,631 | -67 | $66,722 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -28.0% | 1,202 | -93 | $85,954 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -26.3% | 1,245 | -88 | $77,141 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 15.5% | 3,297 | 52 | $25,478 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 23.2% | 3,638 | 77 | $22,095 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 0.4% | 2,461 | 1 | $30,649 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -0.4% | 2,378 | -1 | $30,918 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 27.2% | 3,718 | 91 | $19,115 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 8.8% | 2,758 | 29 | $23,603 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 28.9% | 3,726 | 96 | $17,374 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 19.0% | 3,188 | 63 | $15,419 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -25.0% | 950 | -83 | $51,115 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -22.7% | 1,025 | -76 | $46,890 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -16.9% | 1,275 | -56 | $30,734 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -11.9% | 1,485 | -40 | $24,639 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -21.6% | 960 | -72 | $36,417 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 18.5% | 2,925 | 62 | $9,818 | $28,717,189 | 1 |