Domestic Box Office Results for 2021 Week 20 (3-Day May 14 - May 16)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 20.4% | 3,979 | 68 | $106,937 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -18.9% | 1,973 | -63 | $204,937 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 28.2% | 4,292 | 94 | $79,479 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -9.6% | 2,360 | -32 | $138,288 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -8.7% | 2,363 | -29 | $85,672 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 23.0% | 3,909 | 77 | $42,454 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 17.9% | 3,616 | 60 | $34,965 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 16.6% | 3,510 | 55 | $34,740 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -18.4% | 1,718 | -61 | $63,343 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 22.2% | 3,708 | 74 | $27,863 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -29.7% | 1,076 | -99 | $89,257 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 17.3% | 3,383 | 58 | $24,830 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -7.8% | 2,088 | -26 | $38,497 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -9.3% | 1,976 | -31 | $38,171 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 1.6% | 2,482 | 5 | $29,623 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 0.6% | 2,392 | 2 | $29,711 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -19.0% | 1,369 | -63 | $47,552 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 9.3% | 2,747 | 31 | $23,566 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -9.7% | 1,753 | -32 | $28,042 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -19.7% | 1,216 | -66 | $39,934 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -9.5% | 1,683 | -32 | $28,557 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -12.9% | 1,477 | -43 | $26,530 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 4.6% | 2,308 | 15 | $15,853 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 23.6% | 3,220 | 79 | $10,857 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -8.2% | 1,588 | -27 | $18,084 | $28,717,189 | 1 |