Domestic Box Office Results for 2021 Week 21 (3-Day May 21 - May 23)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 20.9% | 4,003 | 70 | $106,295 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 0.6% | 2,950 | 2 | $137,064 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -22.2% | 1,772 | -74 | $192,507 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 21.1% | 3,897 | 70 | $83,746 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -11.6% | 2,220 | -39 | $91,191 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -6.2% | 2,449 | -21 | $67,764 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 27.0% | 4,072 | 90 | $31,049 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -29.2% | 1,220 | -97 | $99,948 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 8.1% | 3,044 | 27 | $35,750 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -25.8% | 1,311 | -86 | $78,808 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -20.9% | 1,513 | -70 | $63,477 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -16.7% | 1,687 | -56 | $49,793 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 19.3% | 3,444 | 64 | $23,340 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 2.3% | 2,557 | 8 | $29,498 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 19.3% | 3,363 | 64 | $21,863 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -4.0% | 2,159 | -13 | $32,917 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -17.3% | 1,453 | -58 | $44,803 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -5.8% | 1,991 | -19 | $32,514 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -21.8% | 1,148 | -73 | $42,820 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 10.6% | 2,729 | 35 | $17,794 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -29.1% | 707 | -97 | $67,980 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 5.6% | 2,398 | 19 | $16,341 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 18.5% | 3,004 | 62 | $12,180 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -1.2% | 1,982 | -4 | $17,639 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -28.3% | 583 | -94 | $49,258 | $28,717,189 | 1 |