Domestic Box Office Results for 2021 Week 22 (3-Day May 28 - May 30)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -29.2% | 1,498 | -97 | $284,046 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -23.6% | 1,741 | -79 | $232,246 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 9.0% | 3,332 | 30 | $102,378 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 20.9% | 3,886 | 70 | $83,983 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -23.7% | 1,615 | -79 | $125,352 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -12.7% | 2,123 | -42 | $78,169 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 7.0% | 3,070 | 23 | $41,183 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -7.6% | 2,299 | -25 | $53,039 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -0.3% | 2,627 | -1 | $41,425 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 22.3% | 3,714 | 74 | $27,818 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 0.9% | 2,604 | 3 | $36,882 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 25.0% | 3,770 | 83 | $22,281 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 5.6% | 2,762 | 19 | $29,103 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -10.3% | 1,924 | -34 | $39,203 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -11.3% | 1,834 | -38 | $40,089 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 5.9% | 2,657 | 20 | $26,748 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 7.4% | 2,688 | 25 | $24,218 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -25.4% | 1,011 | -85 | $64,030 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -2.8% | 2,102 | -9 | $23,386 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -16.0% | 1,402 | -53 | $34,636 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 15.1% | 2,916 | 50 | $16,482 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -3.8% | 1,931 | -13 | $20,293 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 23.8% | 3,270 | 79 | $11,189 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -4.2% | 1,831 | -14 | $19,093 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 10.2% | 2,509 | 34 | $11,446 | $28,717,189 | 1 |