Domestic Box Office Results for 2021 Week 23 (3-Day Jun 4 - Jun 6)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -9.0% | 2,508 | -30 | $169,657 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -17.1% | 2,067 | -57 | $195,617 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 8.5% | 3,307 | 28 | $103,151 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -4.3% | 2,623 | -14 | $124,422 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -9.1% | 2,345 | -30 | $86,330 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -0.7% | 2,725 | -2 | $60,900 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 9.1% | 3,177 | 30 | $39,796 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -28.6% | 1,251 | -95 | $97,471 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -21.9% | 1,544 | -73 | $70,482 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -1.5% | 2,525 | -5 | $40,918 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -28.8% | 1,118 | -96 | $85,903 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -15.6% | 1,740 | -52 | $48,276 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 11.0% | 3,028 | 37 | $26,546 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 3.5% | 2,616 | 12 | $28,833 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -6.9% | 2,055 | -23 | $35,778 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 24.3% | 3,575 | 81 | $19,879 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 22.6% | 3,451 | 75 | $18,864 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 22.4% | 3,400 | 75 | $19,040 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -18.5% | 1,313 | -62 | $37,439 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 20.6% | 3,228 | 69 | $15,043 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -21.2% | 1,100 | -71 | $43,693 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -9.4% | 1,648 | -31 | $23,777 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -26.2% | 771 | -87 | $47,456 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -14.6% | 1,310 | -49 | $26,687 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -4.7% | 1,767 | -16 | $16,252 | $28,717,189 | 1 |