Domestic Box Office Results for 2021 Week 25 (3-Day Jun 18 - Jun 20)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 1.0% | 3,009 | 3 | $141,409 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -27.7% | 1,535 | -92 | $263,414 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -28.1% | 1,477 | -94 | $230,956 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 28.8% | 4,282 | 96 | $76,217 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 4.7% | 3,034 | 16 | $66,725 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -5.0% | 2,510 | -17 | $66,117 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 16.7% | 3,556 | 56 | $35,555 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -18.1% | 1,776 | -60 | $68,658 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -17.7% | 1,754 | -59 | $62,043 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -19.3% | 1,637 | -64 | $63,114 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -10.2% | 2,051 | -34 | $46,826 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -3.2% | 2,360 | -11 | $35,594 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 16.2% | 3,291 | 54 | $24,425 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 17.7% | 3,323 | 59 | $22,698 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 23.8% | 3,591 | 79 | $20,475 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -27.7% | 975 | -92 | $72,890 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 14.3% | 3,034 | 48 | $21,456 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 12.3% | 2,895 | 41 | $22,361 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -17.8% | 1,348 | -59 | $36,467 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -11.2% | 1,641 | -37 | $29,591 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -2.5% | 2,034 | -8 | $23,629 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 5.9% | 2,414 | 20 | $16,233 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 3.9% | 2,273 | 13 | $16,097 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 0.4% | 2,059 | 1 | $16,979 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -21.8% | 910 | -73 | $31,557 | $28,717,189 | 1 |