Domestic Box Office Results for 2021 Week 37 (3-Day Sep 10 - Sep 12)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -18.2% | 2,052 | -61 | $207,359 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 18.5% | 3,843 | 62 | $105,215 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -3.3% | 2,715 | -11 | $125,643 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 6.1% | 3,143 | 20 | $103,837 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -23.9% | 1,605 | -80 | $126,133 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 27.2% | 4,119 | 91 | $40,290 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 24.8% | 3,960 | 83 | $31,927 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -29.9% | 1,183 | -100 | $103,074 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 19.7% | 3,623 | 66 | $30,037 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 13.3% | 3,264 | 44 | $31,653 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 19.9% | 3,557 | 66 | $27,000 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -0.8% | 2,480 | -3 | $33,871 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -13.7% | 1,793 | -46 | $44,831 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 18.7% | 3,374 | 62 | $22,355 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -10.3% | 1,883 | -34 | $39,046 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -11.8% | 1,772 | -39 | $40,106 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 14.6% | 3,048 | 49 | $21,358 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 11.5% | 2,855 | 38 | $22,674 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 11.3% | 2,803 | 38 | $17,537 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -1.3% | 2,133 | -4 | $22,766 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -28.6% | 728 | -95 | $66,019 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 3.7% | 2,307 | 12 | $16,985 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -8.1% | 1,676 | -27 | $21,831 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -18.7% | 1,106 | -62 | $31,609 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -27.9% | 606 | -93 | $47,388 | $28,717,189 | 1 |