Domestic Box Office Results for 2021 Week 38 (3-Day Sep 17 - Sep 19)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 18.3% | 3,875 | 61 | $109,807 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -15.2% | 2,160 | -51 | $187,194 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | - | 2,880 | - | $118,445 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -28.2% | 1,430 | -94 | $228,223 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -18.1% | 1,894 | -60 | $106,887 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -10.6% | 2,231 | -35 | $74,385 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 23.3% | 3,884 | 78 | $32,552 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -12.2% | 2,068 | -41 | $58,963 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -19.9% | 1,646 | -66 | $66,114 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 16.3% | 3,415 | 54 | $30,254 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -2.2% | 2,448 | -7 | $39,232 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 14.0% | 3,222 | 47 | $26,071 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 23.9% | 3,677 | 80 | $21,861 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 7.6% | 2,818 | 25 | $26,766 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -18.3% | 1,487 | -61 | $49,445 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 11.2% | 2,920 | 37 | $24,338 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 9.0% | 2,770 | 30 | $23,501 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -5.7% | 1,993 | -19 | $32,481 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 4.1% | 2,443 | 14 | $20,122 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 5.8% | 2,492 | 19 | $19,486 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -22.9% | 1,013 | -76 | $47,445 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -20.9% | 1,073 | -70 | $36,519 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -1.2% | 2,019 | -4 | $18,122 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 19.4% | 3,008 | 65 | $11,622 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -3.4% | 1,828 | -11 | $15,710 | $28,717,189 | 1 |