Domestic Box Office Results for 2021 Week 39 (3-Day Sep 24 - Sep 26)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 25.4% | 4,231 | 85 | $100,567 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -17.3% | 2,056 | -58 | $196,663 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 13.0% | 3,529 | 43 | $96,662 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -22.5% | 1,714 | -75 | $190,408 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 19.2% | 3,759 | 64 | $53,856 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 27.3% | 4,126 | 91 | $40,221 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 10.9% | 3,263 | 36 | $38,747 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -1.1% | 2,626 | -4 | $46,434 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 26.8% | 3,979 | 89 | $27,350 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 16.3% | 3,416 | 54 | $30,245 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 10.2% | 3,068 | 34 | $31,304 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 27.0% | 3,868 | 90 | $21,717 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 7.8% | 2,871 | 26 | $27,998 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -1.0% | 2,389 | -3 | $31,572 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -26.4% | 1,081 | -88 | $68,015 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -20.6% | 1,328 | -69 | $53,515 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 0.3% | 2,333 | 1 | $27,903 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -2.2% | 2,168 | -7 | $29,859 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 25.5% | 3,517 | 85 | $13,977 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 3.6% | 2,381 | 12 | $20,395 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -28.1% | 754 | -94 | $63,743 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 28.7% | 3,554 | 96 | $11,026 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 23.0% | 3,232 | 77 | $11,321 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 21.7% | 3,127 | 72 | $11,180 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 28.5% | 3,425 | 95 | $8,385 | $28,717,189 | 1 |