Domestic Box Office Results for 2021 Week 4 (3-Day Jan 22 - Jan 24)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -29.5% | 1,485 | -98 | $286,533 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -12.7% | 2,286 | -42 | $176,877 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 6.2% | 3,191 | 21 | $106,901 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 21.9% | 3,933 | 73 | $82,980 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 29.9% | 4,296 | 100 | $47,124 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -10.8% | 2,222 | -36 | $74,686 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -6.0% | 2,421 | -20 | $52,223 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -29.3% | 1,213 | -98 | $100,524 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -24.8% | 1,398 | -83 | $77,843 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -12.9% | 1,955 | -43 | $52,848 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -1.7% | 2,475 | -6 | $38,804 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 22.8% | 3,659 | 76 | $22,957 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -13.9% | 1,785 | -46 | $45,032 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -9.4% | 1,969 | -31 | $38,307 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -3.2% | 2,240 | -11 | $32,823 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -25.9% | 1,064 | -86 | $66,793 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 24.6% | 3,548 | 82 | $18,348 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 22.4% | 3,398 | 75 | $19,051 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 18.5% | 3,165 | 62 | $15,531 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -4.5% | 1,977 | -15 | $24,562 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 17.1% | 3,014 | 57 | $15,946 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -1.3% | 2,055 | -4 | $19,068 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 12.8% | 2,721 | 43 | $13,447 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -21.4% | 971 | -71 | $36,004 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 3.6% | 2,179 | 12 | $13,179 | $28,717,189 | 1 |