Domestic Box Office Results for 2021 Week 40 (3-Day Oct 1 - Oct 3)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -29.7% | 1,476 | -99 | $288,280 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 21.1% | 3,976 | 70 | $101,695 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 21.3% | 3,945 | 71 | $86,469 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 1.8% | 2,928 | 6 | $111,461 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -16.8% | 1,958 | -56 | $103,393 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -12.3% | 2,145 | -41 | $77,367 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -6.0% | 2,419 | -20 | $52,266 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -11.2% | 2,120 | -37 | $57,517 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 16.6% | 3,472 | 55 | $31,343 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -13.6% | 1,921 | -45 | $53,783 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -8.1% | 2,157 | -27 | $44,525 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -24.1% | 1,316 | -80 | $63,831 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 11.9% | 3,075 | 40 | $26,141 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -26.1% | 1,137 | -87 | $66,338 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 14.5% | 3,124 | 48 | $23,535 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -20.9% | 1,314 | -70 | $54,085 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -8.7% | 1,887 | -29 | $34,498 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -27.6% | 898 | -92 | $72,088 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -20.5% | 1,217 | -68 | $40,392 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 1.9% | 2,294 | 6 | $21,168 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 7.1% | 2,514 | 24 | $19,118 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 29.3% | 3,584 | 98 | $10,933 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 26.0% | 3,382 | 87 | $10,819 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 8.2% | 2,451 | 27 | $14,264 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -23.5% | 823 | -78 | $34,893 | $28,717,189 | 1 |