Domestic Box Office Results for 2021 Week 41 (3-Day Oct 8 - Oct 10)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 25.3% | 4,223 | 84 | $100,758 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 29.5% | 4,395 | 98 | $92,000 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -19.2% | 1,919 | -64 | $177,760 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -5.2% | 2,578 | -17 | $126,594 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 18.0% | 3,698 | 60 | $54,744 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 10.5% | 3,284 | 35 | $50,534 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -5.7% | 2,435 | -19 | $51,923 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -29.2% | 1,220 | -97 | $99,948 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -11.4% | 2,070 | -38 | $52,572 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 25.3% | 3,866 | 84 | $26,724 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 10.1% | 3,066 | 34 | $31,324 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -1.6% | 2,439 | -5 | $34,441 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -6.2% | 2,169 | -21 | $37,060 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 12.5% | 3,066 | 42 | $24,601 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -29.6% | 920 | -99 | $79,917 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 29.5% | 3,837 | 98 | $18,522 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -27.7% | 935 | -92 | $69,624 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 2.4% | 2,401 | 8 | $26,962 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 5.8% | 2,532 | 19 | $19,414 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -28.2% | 790 | -94 | $61,468 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 10.9% | 2,703 | 36 | $17,781 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 26.4% | 3,441 | 88 | $11,388 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -1.2% | 2,019 | -4 | $18,122 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -1.2% | 1,979 | -4 | $17,665 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 3.6% | 2,178 | 12 | $13,185 | $28,717,189 | 1 |