Domestic Box Office Results for 2021 Week 42 (3-Day Oct 15 - Oct 17)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 22.9% | 4,104 | 76 | $103,680 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 26.8% | 4,261 | 89 | $94,893 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -18.0% | 1,981 | -60 | $172,197 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 28.4% | 4,259 | 95 | $76,628 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -2.6% | 2,672 | -9 | $75,765 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -29.1% | 1,306 | -97 | $127,070 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 19.9% | 3,716 | 66 | $34,024 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 27.4% | 4,052 | 91 | $30,093 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 21.5% | 3,714 | 72 | $29,301 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -5.1% | 2,346 | -17 | $44,040 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -8.7% | 2,123 | -29 | $45,238 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -2.7% | 2,387 | -9 | $35,191 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 24.0% | 3,682 | 80 | $21,831 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 25.6% | 3,722 | 85 | $20,265 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 0.9% | 2,443 | 3 | $30,096 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -0.2% | 2,351 | -1 | $30,229 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 13.0% | 2,971 | 43 | $21,911 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 7.5% | 2,654 | 25 | $24,391 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -25.3% | 973 | -84 | $50,521 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -4.1% | 1,994 | -14 | $24,353 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 19.7% | 3,147 | 66 | $15,272 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -27.4% | 749 | -91 | $52,317 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -9.2% | 1,622 | -31 | $22,558 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 15.7% | 2,823 | 52 | $12,384 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -2.3% | 1,883 | -8 | $15,251 | $28,717,189 | 1 |