Domestic Box Office Results for 2021 Week 43 (3-Day Oct 22 - Oct 24)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 3.9% | 3,153 | 13 | $134,951 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -15.6% | 2,141 | -52 | $188,856 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -27.2% | 1,518 | -91 | $224,718 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 4.3% | 3,053 | 14 | $106,898 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -26.7% | 1,464 | -89 | $138,281 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -11.3% | 2,193 | -38 | $75,674 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -1.2% | 2,658 | -4 | $47,567 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -11.2% | 2,118 | -37 | $57,571 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -12.9% | 1,994 | -43 | $54,576 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -7.0% | 2,249 | -23 | $45,939 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -15.6% | 1,780 | -52 | $53,955 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 12.8% | 3,158 | 43 | $26,599 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -23.8% | 1,291 | -79 | $62,264 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -4.0% | 2,238 | -13 | $33,703 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -1.7% | 2,313 | -6 | $31,787 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 19.9% | 3,355 | 66 | $21,183 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 29.6% | 3,801 | 99 | $17,127 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -8.4% | 1,862 | -28 | $34,766 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 6.1% | 2,546 | 20 | $19,308 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 21.4% | 3,269 | 71 | $14,855 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 16.2% | 2,968 | 54 | $16,193 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -12.1% | 1,517 | -40 | $25,831 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -12.8% | 1,439 | -43 | $25,426 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -2.3% | 1,925 | -8 | $18,161 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -0.7% | 1,965 | -2 | $14,614 | $28,717,189 | 1 |