Domestic Box Office Results for 2021 Week 45 (3-Day Nov 5 - Nov 7)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 13.1% | 3,616 | 44 | $117,672 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 9.8% | 3,412 | 33 | $118,505 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -11.3% | 2,315 | -38 | $147,353 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 14.2% | 3,549 | 47 | $91,958 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 4.0% | 3,001 | 13 | $67,459 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 24.9% | 4,005 | 83 | $41,436 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -8.9% | 2,275 | -30 | $55,575 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -23.1% | 1,527 | -77 | $79,853 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 4.5% | 2,867 | 15 | $37,957 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 13.3% | 3,263 | 44 | $31,663 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -10.3% | 2,043 | -34 | $47,009 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 25.5% | 3,793 | 85 | $22,146 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -6.4% | 2,161 | -21 | $37,197 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 17.3% | 3,305 | 58 | $22,822 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -16.5% | 1,576 | -55 | $46,652 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 12.0% | 2,961 | 40 | $24,001 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -0.9% | 2,276 | -3 | $28,602 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -7.4% | 1,909 | -25 | $33,910 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | - | 2,238 | - | $21,965 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 13.2% | 2,860 | 44 | $16,979 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -2.6% | 2,028 | -9 | $23,699 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -16.5% | 1,297 | -55 | $30,212 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 5.6% | 2,360 | 19 | $15,504 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -17.8% | 1,150 | -59 | $30,400 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -23.5% | 826 | -78 | $34,767 | $28,717,189 | 1 |