Domestic Box Office Results for 2021 Week 46 (3-Day Nov 12 - Nov 14)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 13.6% | 3,640 | 45 | $116,896 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 9.1% | 3,373 | 30 | $119,875 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -18.4% | 1,961 | -61 | $173,953 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 11.4% | 3,409 | 38 | $95,735 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -1.2% | 2,741 | -4 | $73,858 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -23.0% | 1,612 | -77 | $102,949 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -1.9% | 2,623 | -6 | $48,201 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -17.0% | 1,830 | -57 | $66,632 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 2.9% | 2,786 | 10 | $39,061 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -12.1% | 1,994 | -40 | $51,814 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -27.3% | 1,195 | -91 | $80,368 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -3.4% | 2,351 | -11 | $35,730 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 8.6% | 2,911 | 29 | $27,613 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 16.5% | 3,264 | 55 | $23,109 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 8.4% | 2,818 | 28 | $26,091 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -20.0% | 1,358 | -67 | $52,333 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -4.5% | 2,093 | -15 | $31,103 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -22.6% | 1,151 | -75 | $56,242 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -27.8% | 850 | -93 | $57,832 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -7.3% | 1,833 | -24 | $26,492 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 23.9% | 3,356 | 80 | $14,321 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -20.8% | 1,081 | -69 | $36,249 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -29.5% | 604 | -98 | $60,577 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -17.6% | 1,159 | -59 | $30,164 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 22.3% | 3,113 | 74 | $9,225 | $28,717,189 | 1 |