Domestic Box Office Results for 2021 Week 48 (3-Day Nov 26 - Nov 28)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -2.1% | 2,857 | -7 | $148,933 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 7.2% | 3,281 | 24 | $123,237 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -17.1% | 2,025 | -57 | $168,455 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 9.5% | 3,313 | 32 | $98,509 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 28.9% | 4,247 | 96 | $47,667 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 18.2% | 3,669 | 61 | $45,231 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -12.2% | 2,108 | -41 | $59,977 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -19.2% | 1,720 | -64 | $70,893 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 10.1% | 3,147 | 34 | $34,580 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 1.8% | 2,689 | 6 | $38,422 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 15.2% | 3,321 | 51 | $28,919 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 1.7% | 2,606 | 6 | $32,234 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 23.1% | 3,634 | 77 | $22,120 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 27.5% | 3,817 | 92 | $19,761 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 25.6% | 3,682 | 85 | $19,969 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -16.1% | 1,553 | -54 | $45,762 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -23.0% | 1,169 | -77 | $55,687 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -8.7% | 1,845 | -29 | $35,087 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -1.9% | 2,144 | -6 | $22,928 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -10.8% | 1,661 | -36 | $29,235 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 25.6% | 3,438 | 85 | $13,980 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 4.8% | 2,361 | 16 | $16,597 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -25.6% | 800 | -85 | $45,735 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -16.0% | 1,240 | -53 | $28,194 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 2.2% | 2,111 | 7 | $13,604 | $28,717,189 | 1 |