Domestic Box Office Results for 2021 Week 49 (3-Day Dec 3 - Dec 5)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -23.7% | 1,777 | -79 | $239,449 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -28.3% | 1,506 | -94 | $268,486 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 19.3% | 3,845 | 64 | $88,718 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -7.7% | 2,457 | -26 | $132,828 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -11.5% | 2,224 | -38 | $91,027 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -15.2% | 2,000 | -51 | $82,977 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 26.5% | 4,045 | 88 | $31,256 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -5.7% | 2,394 | -19 | $50,934 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -27.1% | 1,284 | -90 | $84,754 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 12.8% | 3,241 | 43 | $31,878 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 5.6% | 2,841 | 19 | $33,805 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 7.2% | 2,878 | 24 | $29,187 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -8.4% | 2,060 | -28 | $39,021 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 10.5% | 2,967 | 35 | $25,422 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -11.6% | 1,822 | -39 | $40,354 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 4.3% | 2,575 | 14 | $27,599 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -15.7% | 1,535 | -52 | $42,409 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -24.1% | 1,077 | -80 | $60,107 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 28.5% | 3,665 | 95 | $13,413 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 13.2% | 2,862 | 44 | $16,967 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -4.0% | 1,959 | -13 | $24,534 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -22.7% | 984 | -76 | $39,822 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 16.4% | 2,899 | 55 | $12,621 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 3.0% | 2,192 | 10 | $15,949 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 13.7% | 2,685 | 46 | $10,695 | $28,717,189 | 1 |