Domestic Box Office Results for 2021 Week 50 (3-Day Dec 10 - Dec 12)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -14.8% | 2,220 | -49 | $191,667 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 26.2% | 4,231 | 87 | $95,566 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -4.5% | 2,655 | -15 | $128,483 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -18.8% | 1,900 | -63 | $171,768 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 4.0% | 3,002 | 13 | $67,436 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 15.2% | 3,521 | 51 | $47,132 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -3.7% | 2,533 | -12 | $49,914 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -2.1% | 2,574 | -7 | $47,372 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -23.1% | 1,485 | -77 | $73,282 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 1.3% | 2,665 | 4 | $38,768 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -16.7% | 1,725 | -56 | $55,675 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 8.7% | 2,956 | 29 | $28,417 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 9.2% | 2,941 | 31 | $27,332 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 19.9% | 3,437 | 66 | $21,945 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 22.4% | 3,522 | 75 | $20,876 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -13.2% | 1,699 | -44 | $41,829 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 29.6% | 3,802 | 99 | $17,122 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 7.5% | 2,655 | 25 | $24,382 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 19.1% | 3,195 | 64 | $15,386 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -23.5% | 1,024 | -78 | $47,421 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 0.7% | 2,195 | 2 | $21,896 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -15.5% | 1,347 | -52 | $29,091 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -17.2% | 1,221 | -57 | $29,966 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -26.9% | 696 | -90 | $50,230 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 9.7% | 2,486 | 32 | $11,552 | $28,717,189 | 1 |