Domestic Box Office Results for 2021 Week 51 (3-Day Dec 17 - Dec 19)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 28.9% | 4,405 | 96 | $96,595 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -22.8% | 1,781 | -76 | $227,030 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -7.2% | 2,520 | -24 | $135,366 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 9.7% | 3,323 | 32 | $98,212 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -22.1% | 1,697 | -74 | $119,295 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 25.5% | 4,036 | 85 | $41,118 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -3.2% | 2,559 | -11 | $49,407 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -11.0% | 2,130 | -37 | $57,247 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 12.1% | 3,245 | 40 | $33,536 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -0.8% | 2,560 | -3 | $40,358 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -12.6% | 1,932 | -42 | $49,710 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -19.7% | 1,536 | -66 | $54,688 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 22.7% | 3,613 | 76 | $22,248 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 29.6% | 3,918 | 99 | $19,251 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 6.2% | 2,710 | 21 | $27,131 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -25.9% | 1,066 | -86 | $66,668 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -12.6% | 1,692 | -42 | $38,474 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -11.5% | 1,705 | -38 | $37,968 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -7.0% | 1,892 | -23 | $25,982 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 7.0% | 2,548 | 23 | $19,058 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 6.6% | 2,492 | 22 | $19,287 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -2.9% | 1,974 | -10 | $19,851 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 24.3% | 3,295 | 81 | $11,104 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -24.3% | 824 | -81 | $42,427 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 9.0% | 2,450 | 30 | $11,721 | $28,717,189 | 1 |