Domestic Box Office Results for 2021 Week 52 (3-Day Dec 24 - Dec 26)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -13.6% | 2,280 | -45 | $186,623 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -4.0% | 2,722 | -13 | $148,545 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 9.8% | 3,370 | 33 | $101,223 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -15.7% | 2,056 | -52 | $158,735 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 22.8% | 3,940 | 76 | $51,382 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 21.2% | 3,819 | 71 | $43,455 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -13.8% | 2,029 | -46 | $62,313 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -0.6% | 2,649 | -2 | $46,031 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 27.4% | 4,009 | 91 | $27,145 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 17.7% | 3,487 | 59 | $29,629 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 24.5% | 3,787 | 82 | $25,360 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 23.4% | 3,692 | 78 | $22,752 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -24.3% | 1,265 | -81 | $63,544 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -12.1% | 1,837 | -40 | $41,059 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 29.0% | 3,852 | 97 | $19,087 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -20.0% | 1,360 | -67 | $52,256 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 17.1% | 3,173 | 57 | $20,516 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -29.5% | 803 | -98 | $80,616 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 9.2% | 2,702 | 31 | $18,193 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 13.9% | 2,896 | 46 | $16,768 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -3.8% | 1,968 | -13 | $24,422 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 29.9% | 3,614 | 100 | $10,843 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -5.6% | 1,798 | -19 | $20,349 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 4.6% | 2,272 | 15 | $15,387 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 7.6% | 2,380 | 25 | $12,066 | $28,717,189 | 1 |