Domestic Box Office Results for 2021 Week 6 (3-Day Feb 5 - Feb 7)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 7.0% | 3,309 | 23 | $128,589 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -5.0% | 2,670 | -17 | $151,438 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 10.3% | 3,396 | 34 | $100,448 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -7.9% | 2,446 | -26 | $133,426 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -19.9% | 1,804 | -66 | $112,219 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -12.9% | 2,115 | -43 | $78,465 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 13.2% | 3,381 | 44 | $37,395 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -11.5% | 2,103 | -38 | $57,982 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 11.4% | 3,212 | 38 | $33,880 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -1.4% | 2,529 | -5 | $40,853 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -8.3% | 2,143 | -28 | $44,816 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -16.3% | 1,705 | -54 | $49,267 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 6.4% | 2,799 | 21 | $28,718 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -7.1% | 2,084 | -24 | $36,193 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 12.8% | 3,041 | 43 | $24,178 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 12.7% | 2,995 | 42 | $23,729 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 15.5% | 3,094 | 52 | $21,040 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -19.3% | 1,314 | -64 | $49,265 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 21.6% | 3,321 | 72 | $14,802 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 8.0% | 2,599 | 27 | $18,684 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 10.9% | 2,706 | 36 | $17,761 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 6.8% | 2,461 | 23 | $15,923 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 2.4% | 2,198 | 8 | $16,646 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -18.5% | 1,113 | -62 | $31,411 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -16.2% | 1,192 | -54 | $24,092 | $28,717,189 | 1 |