Domestic Box Office Results for 2022 Week 16 (3-Day Apr 15 - Apr 17)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 14.9% | 3,706 | 50 | $114,814 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -23.0% | 1,769 | -77 | $228,570 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 23.3% | 4,043 | 78 | $84,373 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -23.7% | 1,653 | -79 | $197,434 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 4.0% | 2,998 | 13 | $67,526 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 12.2% | 3,368 | 41 | $49,273 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 16.9% | 3,563 | 56 | $35,485 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -12.5% | 2,055 | -42 | $59,336 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -26.9% | 1,295 | -90 | $84,034 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -0.4% | 2,580 | -1 | $40,045 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 23.7% | 3,744 | 79 | $25,652 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | 13.3% | 3,187 | 44 | $26,357 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -19.9% | 1,485 | -66 | $54,130 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 15.3% | 3,204 | 51 | $23,541 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -6.0% | 2,099 | -20 | $35,028 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -20.9% | 1,314 | -70 | $54,085 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -4.8% | 2,079 | -16 | $31,312 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -22.5% | 1,155 | -75 | $56,047 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 3.8% | 2,431 | 13 | $20,221 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -15.9% | 1,404 | -53 | $34,586 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 14.2% | 2,868 | 47 | $16,758 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -5.9% | 1,827 | -20 | $21,448 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -11.3% | 1,517 | -38 | $24,119 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -11.5% | 1,467 | -38 | $23,831 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 22.9% | 3,144 | 76 | $9,134 | $28,717,189 | 1 |