Domestic Box Office Results for 2022 Week 19 (3-Day May 6 - May 8)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 17.2% | 3,819 | 57 | $111,417 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -4.9% | 2,675 | -16 | $151,155 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -7.4% | 2,508 | -25 | $136,014 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | -11.4% | 2,272 | -38 | $143,644 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 22.4% | 3,919 | 75 | $51,657 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -19.9% | 1,765 | -66 | $94,024 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | -16.5% | 1,893 | -55 | $66,789 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -8.5% | 2,255 | -28 | $54,074 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | 23.7% | 3,826 | 79 | $28,443 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -23.7% | 1,416 | -79 | $72,964 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 25.4% | 3,830 | 85 | $25,076 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -14.5% | 1,793 | -48 | $46,849 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | -14.7% | 1,744 | -49 | $46,091 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 10.0% | 2,941 | 33 | $25,646 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 15.0% | 3,148 | 50 | $23,356 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 23.0% | 3,511 | 77 | $20,242 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -8.0% | 1,922 | -27 | $33,870 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -5.7% | 1,993 | -19 | $32,481 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 24.4% | 3,461 | 81 | $14,203 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 29.2% | 3,659 | 97 | $13,271 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -2.2% | 2,052 | -7 | $23,422 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 6.8% | 2,459 | 23 | $15,935 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -7.1% | 1,723 | -24 | $21,235 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -13.4% | 1,369 | -45 | $25,537 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | -10.9% | 1,457 | -36 | $19,710 | $28,717,189 | 1 |