Domestic Box Office Results for 2022 Week 20 (3-Day May 13 - May 15)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -23.4% | 1,790 | -78 | $237,710 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 24.9% | 4,165 | 83 | $97,080 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | -0.4% | 2,858 | -1 | $119,357 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 0.3% | 2,857 | 1 | $114,231 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | 3.1% | 2,956 | 10 | $68,486 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | 0.1% | 2,766 | - | $59,998 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 2.3% | 2,835 | 8 | $44,597 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -24.7% | 1,443 | -82 | $84,502 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -0.1% | 2,634 | - | $41,315 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -6.2% | 2,289 | -21 | $45,136 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 10.5% | 3,083 | 35 | $31,151 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -16.3% | 1,706 | -54 | $49,239 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 17.9% | 3,375 | 60 | $23,817 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | -15.5% | 1,665 | -52 | $45,301 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | -21.1% | 1,347 | -70 | $54,584 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | 26.1% | 3,664 | 87 | $19,396 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 18.0% | 3,222 | 60 | $20,204 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 15.2% | 3,040 | 51 | $21,294 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | 29.2% | 3,701 | 97 | $13,282 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -16.5% | 1,376 | -55 | $35,290 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -1.2% | 2,099 | -4 | $22,898 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 26.5% | 3,445 | 88 | $11,375 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -17.9% | 1,186 | -60 | $30,850 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | 25.3% | 3,303 | 84 | $10,584 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 29.8% | 3,489 | 99 | $8,231 | $28,717,189 | 1 |