Domestic Box Office Results for 2022 Week 21 (3-Day May 20 - May 22)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | 17.5% | 3,835 | 58 | $110,952 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | -12.5% | 2,297 | -42 | $176,030 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 22.0% | 3,981 | 73 | $85,687 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 3.8% | 3,032 | 13 | $107,638 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -11.8% | 2,210 | -39 | $91,603 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -11.6% | 2,180 | -39 | $76,125 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 20.7% | 3,753 | 69 | $33,688 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | 10.4% | 3,199 | 35 | $38,117 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -26.8% | 1,302 | -89 | $83,582 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | -27.0% | 1,248 | -90 | $82,786 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | 18.1% | 3,463 | 60 | $27,733 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -6.9% | 2,177 | -23 | $38,586 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 13.0% | 3,132 | 43 | $25,665 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 3.0% | 2,589 | 10 | $29,133 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 11.0% | 2,951 | 37 | $24,915 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -21.4% | 1,290 | -71 | $55,092 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | -15.8% | 1,532 | -53 | $42,492 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | 10.9% | 2,827 | 36 | $22,899 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -0.3% | 2,227 | -1 | $22,073 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | 21.7% | 3,283 | 72 | $14,791 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | -10.2% | 1,649 | -34 | $29,146 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | -26.8% | 779 | -89 | $50,302 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | -9.8% | 1,592 | -33 | $22,983 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -5.7% | 1,753 | -19 | $19,943 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 15.2% | 2,760 | 51 | $10,405 | $28,717,189 | 1 |