Domestic Box Office Results for 2022 Week 22 (3-Day May 27 - May 29)
| Rank | Title | Rating | Distributor | Total Weekend | +-LW | Locations | +-LW | Avg. Per Location | Total To-Date | Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | The Super Mario Galaxy Movie | PG | Universal Pictures | $425,500,825 | -8.8% | 2,519 | -29 | $168,917 | $425,500,825 | 1 |
| 2 | Avatar: Fire and Ash | PG-13 | 20th Century Studios | $404,340,010 | 25.8% | 4,212 | 86 | $95,997 | $404,340,010 | 1 |
| 3 | Project Hail Mary | PG-13 | Amazon Studios | $341,121,909 | 23.7% | 4,066 | 79 | $83,896 | $341,121,909 | 1 |
| 4 | Michael | PG-13 | Lionsgate | $326,359,112 | 1.7% | 2,926 | 6 | $111,538 | $326,359,112 | 1 |
| 5 | The Devil Wears Prada 2 | PG-13 | Walt Disney Studios Motion Pictures | $202,443,724 | -5.6% | 2,520 | -19 | $80,335 | $202,443,724 | 1 |
| 6 | Hoppers | PG | Walt Disney Studios Motion Pictures | $165,953,089 | -6.5% | 2,435 | -22 | $68,153 | $165,953,089 | 1 |
| 7 | The Housemaid | R | Lionsgate | $126,432,462 | 2.8% | 2,861 | 9 | $44,192 | $126,432,462 | 1 |
| 8 | Scream 7 | NR | Paramount | $121,935,967 | -23.8% | 1,491 | -79 | $81,781 | $121,935,967 | 1 |
| 9 | Star Wars: The Mandalorian and Grogu | PG-13 | Walt Disney Studios Motion Pictures | $108,823,848 | -11.2% | 2,079 | -37 | $52,344 | $108,823,848 | 1 |
| 10 | GOAT | PG | Sony Pictures Releasing | $103,316,898 | 27.4% | 3,970 | 91 | $26,024 | $103,316,898 | 1 |
| 11 | Marty Supreme | R | A24 | $96,040,064 | -10.4% | 2,042 | -35 | $47,032 | $96,040,064 | 1 |
| 12 | Wuthering Heights | R | Warner Bros Pictures | $84,001,072 | -21.9% | 1,424 | -73 | $58,990 | $84,001,072 | 1 |
| 13 | David | PG | Angel Studios | $80,382,774 | 13.8% | 3,171 | 46 | $25,349 | $80,382,774 | 1 |
| 14 | Mortal Kombat II | R | Warner Bros Pictures | $75,426,256 | 7.7% | 2,827 | 26 | $26,681 | $75,426,256 | 1 |
| 15 | Obsession | R | Focus Features | $73,524,085 | 17.4% | 3,268 | 58 | $22,498 | $73,524,085 | 1 |
| 16 | The SpongeBob Movie: Search for SquarePants | PG | Paramount Pictures International | $71,068,170 | -28.1% | 956 | -94 | $74,339 | $71,068,170 | 1 |
| 17 | Anaconda | PG-13 | Sony Pictures Releasing | $65,098,148 | 28.4% | 3,742 | 95 | $17,397 | $65,098,148 | 1 |
| 18 | Send Help | R | Walt Disney Studios Motion Pictures | $64,734,795 | -20.6% | 1,249 | -69 | $51,829 | $64,734,795 | 1 |
| 19 | The Sheep Detectives | PG | Amazon Studios | $49,157,055 | -28.0% | 840 | -93 | $58,520 | $49,157,055 | 1 |
| 20 | Reminders of Him | PG-13 | Universal Pictures | $48,559,430 | -14.3% | 1,484 | -48 | $32,722 | $48,559,430 | 1 |
| 21 | The Drama | NR | A24 | $48,062,006 | 1.7% | 2,245 | 6 | $21,408 | $48,062,006 | 1 |
| 22 | Song Sung Blue | PG-13 | Focus Features | $39,185,290 | 14.8% | 2,858 | 49 | $13,711 | $39,185,290 | 1 |
| 23 | Crime 101 | R | Amazon Studios | $36,588,336 | 5.0% | 2,331 | 17 | $15,696 | $36,588,336 | 1 |
| 24 | Iron Lung | R | Independent | $34,960,000 | -27.4% | 672 | -91 | $52,024 | $34,960,000 | 1 |
| 25 | Lee Cronin's The Mummy | NR | Warner Bros Pictures | $28,717,189 | 10.8% | 2,539 | 36 | $11,310 | $28,717,189 | 1 |